KEYNOTE: Computational Physiology and the Physiome Project

Time: 9:20 - 9:50   Computational physiology models deal with multiple physical processes (coupled tissue mechanics, electrical activity, fluid flow, etc) at multiple spatial and temporal scales, and in some cases analyze... [ view full abstract ]

Time: 9:20 - 9:50  

Computational physiology models deal with multiple physical processes (coupled tissue mechanics, electrical activity, fluid flow, etc) at multiple spatial and temporal scales, and in some cases analyze integrative biological function in terms of underlying structure and molecular mechanisms. These models are intended both to help understand physiological function and to provide a basis for diagnosing and treating pathologies in a clinical setting. The Physiome Project of the International Union of Physiological Sciences (IUPS) and the Virtual Physiological Human (VPH) project funded by the European Commission are together developing model and data encoding standards, web accessible databases and open source software for multiscale modelling. A new journal called Physiome has recently been launched to publish reproducible and reusable models.
This talk will provide an update on the Physiome Project infrastructure. It will also discuss the use of bond graph theory as a means of ensuring that computational biology models involving multiple physical mechanisms are compliant with principles of mass and energy conservation.