SCARF-1 mediates recruitment of CD4+ T cells to the hepatic sinusoidal endothelium: a new player in the gut-liver axis?

Daniel Patten

University of Birmingham

Dr Daniel Patten is an early career post-doctoral researcher at the Centre for Liver Research, University of Birmingham. His research interests concentrate on the gut-liver axis, with particular focus on the molecules involved in both homeostatic regulation and disease pathology of the liver in response to the high antigenic load which originates from the the gut microbiota. Dr Patten has recently established a independent line of research which is investigating the role of the class F scavenger receptors, SCARF-1 and SCARF-2, in chronic liver injury.


Scavenger receptors are able to bind a diverse range of both endogenous and exogenous antigens; consequently, they play an important role in tissue homeostasis and also contribute to the pathophysiology of a wide range of... [ view full abstract ]


  1. Daniel Patten (University of Birmingham)
  2. Sivesh Kamarajah (University of Birmingham)
  3. Emma Shepherd (University of Birmingham)
  4. Joseph Tickle (University of Birmingham)
  5. David Adams (University of Birmingham)
  6. Chris Weston (University of Birmingham)
  7. Shishir Shetty (University of Birmingham)

Topic Area

Liver sinusoidal liver cells in liver disease


OS2 » Session 2 Gut Microbiota & LSEC (09:00 - Thursday, 15th June, Aula Maxima, Ground Floor)