Mucosal- associated invariant T (MAIT) cells are significantly decreased and exhausted in patients with autoimmune liver disease, but promote primary hepatic stellate cell (HSC) activation

Katrin Böttcher (nee Schölzel)

University College

Katrin is a Physician Scientist working in Prof. Massimo Pinzani's lab at the UCL Institute for Liver and Digestive Health, London, UK. Her research interest is in liver immunology, particularly the role of innate-like T cells for hepatic immune pathology and fibrosis development. Having completed medical school and foundation training at the University of Bonn, Germany, as well as an MD in liver immunology with Prof. Percy Knolle, Katrin jonied Massimo's lab in 2014 as a PhD student. She received an EASL Physician Scientist Fellowship for 12 months after completion of her PhD in 2017 to continue her work on immunological aspects of fibrosis development. She is currently investigating the role of Mucosal-associated invariant T cells (MAIT cells) for fibrosis development in autoimmune liver disease.


MAIT cells are innate-like T cells that are particularly enriched in the liver and alterations in MAIT cell frequency/function have been linked with autoimmune conditions. Autoimmune liver diseases (AILD) are characterised by... [ view full abstract ]


  1. Katrin Böttcher (nee Schölzel) (University College)
  2. Krista Rombouts (University College London)
  3. Francesca Saffioti (Royal Free NHS Foundation Trust)
  4. Davide Roccarina (Royal Free NHS Foundation Trust)
  5. Matteo Rosselli (Royal Free NHS Foundation Trust)
  6. Douglas Thorburn (Royal Free NHS Foundation Trust)
  7. Massimo Pinzani (University College London)

Topic Area

Liver fibrosis


OS9 » Session 9 Hepatic Stellate Cells (11:30 - Saturday, 17th June, Aula Maxima, Ground Floor)