Blockade of platelet function modifies the outcome of acute liver injury

Patricia Lalor

University of Birmingham

Dr Lalor is a senior lecturer in the Centre for Liver Research at the University of Birmingham and has a long standing interest in how cells within the hepatic sinusoids regulate immune cell recruitment and retention in the human liver. Her group is also engaged in projects with a view to understanding the contribution of platelets to liver disease and how alcohol exposure leads to hepatic inflammation. Dr Lalor is also an advocate of wider education for liver health, and has developed and run the successful liver MOOC programme on the Futurelearn platform.


Paracetamol toxicity is a major cause of acute liver failure. The sterile inflammatory response led by neutrophils is critical in mediating liver healing after toxic injury. We have shown that platelets sequester within... [ view full abstract ]


  1. Abhi Chauhan (University of Birmingham)
  2. Steve Watson (University of Birmingham)
  3. David Adams (University of Birmingham)
  4. Patricia Lalor (University of Birmingham)

Topic Area

Liver failure


OS6 » Session 6 Alcohol & Other Liver Injuries (09:00 - Friday, 16th June, Aula Maxima, Ground Floor)