(21) Synthesis and study of novel potential anti-cancer pharmaceuticals

Anti-cancer pharmaceuticals containing a metal such as platinum and ruthenium have grown in use since their first discovery over 50 years ago. Recently, a novel compound, cis-[PtIVCl4(Ind)2], was newly synthesized in the... [ view full abstract ]

Anti-cancer pharmaceuticals containing a metal such as platinum and ruthenium have grown in use since their first discovery over 50 years ago. Recently, a novel compound, cis-[Pt^IVCl₄(Ind)₂], was newly synthesized in the research group of Prof. Bachman and the initial pharmacology testing has shown promise.  As part of this effort, reactivity studies of cis-[Pt^IVCl₄(Ind)₂] were explored where one of the chlorine atoms is replaced by a DNA base such as adenine and known cellular materials such as glutathione. The goal of these studies is more fully understand the possible cellular behavior of these compounds.  Recent studies have also shown that gold coordination complexes could be useful in combating various types of cancer, potentially more effectively than their platinum counterparts.  As such, our next synthetic goal is the creation of a new gold coordination complex derivative with indazole (Ind). Once synthesized this compound’s reactivity as well as interaction with model DNA and cell lines will be analyzed similarly to the new platinum compounds in oder to more fully understand its potential chemotherapeutic, antiproliferative behavior.