Characterization of Polycaprolactone and Rice Husk Silica Composite (PCL-SiO2) by E-Spinning to Apply Supporter for Drug Release

Polycaprolactone (PCL) is an interesting material to apply biomedical field owing to its biodegradability and biocompatibility which is suitable for a specific site with longer healing times. Blending the polymer with other... [ view full abstract ]

Polycaprolactone (PCL) is an interesting material to apply biomedical field owing to its biodegradability and biocompatibility which is suitable for a specific site with longer healing times. Blending the polymer with other materials has degradation property improved with the effective and economic method.

 This study was conducted to fabricate supporter based on Polycaprolactone and Rice husk silica (PCL-SiO₂) by using electrospinning, which was loaded Rhodamine B (RhB) alternative drug for modeling of drug release. Nanoporous silica in the composite was synthesized from rice husk having properties of economic, eco-friendly and high surface area. it drew to enhance the amount of drug loading in the carrier. Electrospinning technique is used to fabricate fibrous component by optimization condition obtained from previous mechanical properties experiments. Release experiment was carried out by the degree of dye absorbance at 544nm by ultraviolet–visible spectroscopy, the RhB in PCL-SiO₂ was released for 1hr ~ 15days at 37°C in phosphate buffer. Furthermore, the Mechanical property was confirmed by DSC, DMA, and TG. Morphology and degree of biodegradation were shown as SEM images and EDS.