Does association between APOE e4 genotype and brain structure increase with older age in UK Biobank? (N = 1,217)

Donald Lyall

University of Glasgow

Donald is a lecturer in Public Health at the Institute of Health and Wellbeing, University of Glasgow. His main interest is in the epidemiology of ageing; what are the factors which make people more or less likely to age well, mentally and physically? His PhD at the University of Edinburgh (2010-2013) focussed on APOE/TOMM40 genotypes and their associations with brain imaging and cognitive phenotypes. 

Abstract

The apolipoprotein e (APOE) e4 genotype is a known risk factor for cognitive decline and dementia, though the differences in brain anatomy which underpin this are unclear. The deleterious effects of this genotype on brain... [ view full abstract ]

Authors

  1. Donald Lyall (University of Glasgow)
  2. Simon Cox (University of Edinburgh)
  3. Carlos Celis-Morales (University of Glasgow)
  4. Daniel Mackay (University of Glasgow)
  5. Rona Strawbridge (University of Glasgow)
  6. Laura Pidgeon (University of Glasgow)
  7. Breda Cullen (University of Glasgow)
  8. Joey Ward (University of Glasgow)
  9. Andrew Mcintosh (University of Edinburgh)
  10. Daniel Smith (University of Edinburgh)
  11. Ian Deary (University of Edinburgh)
  12. Naveed Sattar (University of Glasgow)
  13. Jill Pell (University of Glasgow)

Topic Areas

Ageing , Imaging , Cognition: Education, Intelligence, Memory, Attention

Session

5C-OS » Adult Development and Aging (13:30 - Friday, 30th June, Forum)

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