Childhood Aggression - Results from the ACTION and EAGLE Consortia

Tellervo Korhonen, Meike Bartels and Dorret Boomsma on behalf of the ACTION consortium Childhood aggression and its comorbidities result in a huge burden on affected children, their relatives, teachers, peers, and society... [ view full abstract ]

Tellervo Korhonen, Meike Bartels and Dorret Boomsma on behalf of the ACTION consortium

Childhood aggression and its comorbidities result in a huge burden on affected children, their relatives, teachers, peers, and society as a whole. This symposium is based on data analysed within the ACTION (Aggression in Children: Unravelling gene-environment interplay to inform Treatment and InterventiON strategies) and EAGLE (EArly Genetics and Lifecourse Epidemiology) consortia and focuses on phenotypes and (genetic) epidemiology analyses, including achievements in phenotype harmonisation of aggressive behaviour, comorbidities from teacher-rated behavioural and emotional problem data, and comorbidity between aggression and academic performance. Based on epidemiological data from Sweden, we present the first results regarding childhood aggression and adverse outcomes in young adulthood. This set of presentations is followed by presentations of results from the first large GWA (Genome-wide Association) on aggression in children and adults and a meta-analysis of EWA (Epigenome-wide Association) studies across the lifespan. We carried out a multivariate, multi-rater and multi-age GWAS of aggression and attention problems and present the genetic correlations with adult psychiatric outcomes.