Signatures of negative selection in the genetic architecture of human complex traits


Methods such as LD-score regression and GREML typically assume a fixed relationship between allele frequency and effect size of single-nucleotide polymorphisms (SNPs), whereby rarer variants have larger effects than common... [ view full abstract ]


  1. Jian Zeng (University of Queensland)
  2. Ronald de Vlaming (Vrije Universiteit Amsterdam)
  3. Yang Wu (University of Queensland)
  4. Matthew R. Robinson (University of Queensland)
  5. Luke R. Lloyd-jones (University of Queensland)
  6. Loic Yengo (University of Queensland)
  7. Chloe X. Yap (University of Queensland)
  8. Angli Xue (University of Queensland)
  9. Julia Sidorenko (University of Queensland)
  10. Allan F. Mcrae (University of Queensland)
  11. Joseph E. Powell (University of Queensland)
  12. Grant W. Montgomery (University of Queensland)
  13. Andres Metspalu (University of Tartu)
  14. Tonu Esko (University of Tartu)
  15. Greg Gibson (Georgia Institute of Technology)
  16. Naomi R. Wray (University of Queensland)
  17. Peter M. Visscher (University of Queensland)
  18. Jian Yang (University of Queensland)

Topic Area

Statistical Methods


OS-8A » Statistical Methods II (10:30 - Saturday, 23rd June, Auditorium)



Presentation Files

The presenter has not uploaded any presentation files.