Evaluation of magnetic nanoparticles coated by Taxol imprinted polymer for controlled drug delivery in mouse breast cancer model

Nanoparticles (NPs) have been extensively investigated to improve delivery efficiency of therapeutic and diagnostic agents. In this study, magnetic molecularly imprinted polymer (MIP) was synthesized by using poly DOPA.... [ view full abstract ]

Nanoparticles (NPs) have been extensively investigated to improve delivery efficiency of therapeutic and diagnostic agents. In this study, magnetic molecularly imprinted polymer (MIP) was synthesized by using poly DOPA. Synthesized MIP was used for controlled Taxol delivery in a spontaneous model of breast adenocarcinoma in Balb/c mice in the presence of an external magnetic field. Antitumor effectiveness of Taxol imprinted polymer (Taxol-IP) was evaluated in terms of tumor-growth delay, tumor-doubling time, inhibition ratio, and histopathology. Results showed higher efficacy of Taxol-IP in the presence of magnetic field upon suppressing tumor growth than free Taxol and Taxol-IP without magnetic field. The Taxol and Fe distribution among tissues were evaluated by high-performance liquid chromatography and flame atomic absorption spectrometry, respectively. The obtained results, showed significantly deposition of Taxol in the Taxol-IP treated group with magnetic field. Thus, magnetic Taxol-IP is promising for breast cancer therapy with high efficacy.