Porous metal–organic-framework MIL-100(Fe) as a nanoscale platform for sustainable release of tetracycline

Tetracyclines are a group of broad-spectrum antibiotics used in the treatment of infections of urinary and respiratory tract [1]. Nanoscale porous MIL-100 is a great platform for delivery of broad types of drugs like... [ view full abstract ]

Tetracyclines are a group of broad-spectrum antibiotics used in the treatment of infections of urinary and respiratory tract [1]. Nanoscale porous MIL-100 is a great platform for delivery of broad types of drugs like doxorubicin, ibuprofen and etc [2, 3]. In current research nano MIL-100 was synthesized via Horcajada, et al. method [2]. Sample characterizations carried out with FT-IR, XRD, BET and SEM. Tetracycline (TC) was loaded on MIL-100 in the ratio of 1:3 and the nano-drug-carrier abbreviated as TC@Mil-100. FT-IR spectra confirmed the loading of the drug into the carrier framework. XRD pattern of TC@MIL-100 indicated no pattern of TC. On the other hand, BET analysis showed a 66 percent decrease in available pores and the free surface decreased to 801 Cm3g-1, so it can be concluded that the drug is well dispersed into the nano-pores of MIL-100. The release of TC from MOF was investigated in Simulated Gastric Fluid (SGF) media during 48 hours via UV analysis and it was observed that 96 percent of the drug was sustain released which is an unprecedented amount in comparison with other methods[4]. The results demonstrated the substantially enhanced release of tetracycline as a very slightly soluble drug.
1. Chopra, I. and M. Roberts, Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. Microbiology and molecular biology reviews, 2001. 65(2): p. 232-260.
2. Horcajada, P., et al., Porous metal-organic-framework nanoscale carriers as a potential platform for drug delivery and imaging. Nature materials, 2010. 9(2): p. 172-178.
3. Agostoni, V., et al., Impact of phosphorylation on the encapsulation of nucleoside analogues within porous iron (III) metal–organic framework MIL-100 (Fe) nanoparticles. Journal of Materials Chemistry B, 2013. 1(34): p. 4231-4242.
4. Xie, J.F., et al. In Vitro Release Characterization of Tetracycline Hydrochloride from PLGA/Tetracycline Hydrochloride Electrospun Nanofiber Mats. in Advanced Materials Research. 2013. Trans Tech Publ.

Corresponding author: janet_soleimannejad@khayam.ut.ac.ir