Investigating the Eremostachys laciniata (EL) and Curcumin Longa (CL) encapsulated by Solid Lipid Nanoparticles (SLN) in order to treat the inflammatory diseases

Solid Lipid Nanoparticles (SLN) have emerged as a next-generation drug delivery system with potential applications in pharmaceutical field, cosmetics, research, clinical medicine and other allied sciences. Since a decade,... [ view full abstract ]

Solid Lipid Nanoparticles (SLN) have emerged as a next-generation drug delivery system with potential applications in pharmaceutical field, cosmetics, research, clinical medicine and other allied sciences. Since a decade, trials are being made to utilize SLN as alternative drug delivery system to colloidal drug delivery systems such as lipid emulsions, liposomes and polymeric nanoparticles. Eremostachys laciniata(EL), an Iranian traditional medicinal herb, and Curcumin Longa (CL) are a thick root which are used in local traditional medicine in order to treat the inflammatory diseases. In this project, we are studying nano-encapsulation by using high-pressure homogenizer method with EL and CL effective material mixtures, isolated from rhizomes, and SLN (we call NANO-ChiCo). We compared the NANO-ChiCo with piroxicam ointment in order to treat the inflammatory diseases, e.g., osteoarthritis, rheumatoid arthritis, and reiter’s syndrome. After one month of treatment with the SLN-ChiCo and piroxicam ointment, our recent results for all groups showed significant improvement compared to the control groups.