Capsaicin-Coated silver nanoparticles inhibit amyloid fibril formation of serum albumin

Here, we have synthesized capsaicin-coated silver nanoparticles (AgNPsCap) and have tested their anti-amyloid activity, considering serum albumin (BSA) as a model protein. We found that amyloid formation of BSA was strongly... [ view full abstract ]

Here, we have synthesized capsaicin-coated silver nanoparticles (AgNPsCap) and have tested their anti-amyloid activity, considering serum albumin (BSA) as a model protein. We found that amyloid formation of BSA was strongly suppressed in the presence of AgNPsCap nanoparticles. However, isolated capsaicin and uncapped control nanoparticles did not show such inhibition effect. Bioinformatics analysis reveals CH- and H-bonding interactions between capsaicin and BSA in the formation of protein-ligand complex. These results suggest the significance of surface functionalization of nanoparticles with capsaicin which probably enables capsaicin to effectively interact with the key residues of the amyloidogenic core of BSA.