Co-polymer layered magnetic nanoparticles for hyperthermia treatment of cancer and precise drug delivery

In this paper, we study surface-adapted multifunctional magnetic nanoparticles with bilayer oleic acid, and layered with a poly (N-isopropylacrylamide-co-acrylamide) thermo-reactive copolymer per emulsion Polymerization, for... [ view full abstract ]

In this paper, we study surface-adapted multifunctional magnetic nanoparticles with bilayer oleic acid, and layered with a poly (N-isopropylacrylamide-co-acrylamide) thermo-reactive copolymer per emulsion Polymerization, for the precise management of drugs and applications of magnetic hyperthermia. Nanoparticles Anti-cancer drug doxorubicin was loaded onto the copolymer chains at ambient temperature. Composite (hydrated) nanoparticles with an average diameter of 50 nm were of core shell structure having a magnetic core of about 20 nm and the shell was consisted of organic compounds and water. The magnetic core was superparamagnetic devoid of coercive force and remanence because of the pseudo-single domain nanostructure. The lowest critical solution temperature (LCST) of the heat-sensitive copolymer was witnessed to be approximately 39ºC. The UV visible spectrophotometer was used to examine the loading and discharge profile of the drug at different temperatures, as well as Magnetic heating. There was almost no drug release at normal body temperature. The drug was released at temperatures higher than LCST, which is significant for controlled drug delivery. Magnetic heat generation was studied by exposing the magnetic fluid to an alternating magnetic field of 8.0 kA m ^-1 having 65 kHz frequency. Capture of magnetic nanoparticles in various fields applied to the target drug was analyzed by a simple magnetic capture system.