Influence of combined CYP3A4 and CYP3A5 single-nucleotide polymorphisms on tacrolimus exposure in kidney transplant recipients

Abstract

Tacrolimus (Tac), an immunosuppressant used for the prevention of graft rejection in kidney transplant patients, is characterized by a high interindividual variability of its pharmacokinetics. It is metabolized specifically by... [ view full abstract ]

Authors

  1. Ibtissem Hannachi (Pharmacology Department, University Hospital, Monastir, Tunisia. Faculty of Medicine, University of Monastir, Tunisia.)
  2. Zohra CHADLI (Pharmacology Department, University Hospital, Monastir, Tunisia. Faculty of Medicine, University of Monastir, Tunisia.)
  3. Emna Kerkeni (Pharmacology Department, Faculty of Medicine, University of Monastir, Tunisia.)
  4. Amel Chaabane (Pharmacology Department, University Hospital, Monastir, Tunisia. Faculty of Medicine, University of Monastir, Tunisia.)
  5. Nadia Ben Fredj (Pharmacology Department, University Hospital, Monastir, Tunisia. Faculty of Medicine, University of Monastir, Tunisia.)
  6. Naceur Boughattas (Pharmacology Department, Faculty of Medicine, University of Monastir, Tunisia.)
  7. Karim Aouam (Pharmacology Department, University Hospital, Monastir, Tunisia. Faculty of Medicine, University of Monastir, Tunisia.)

Topic Area

Personalized therapies (cancer, immunology, infectious diseases, clinical case studies, et

Session

PS1 » Poster Session (14:00 - Monday, 25th June, Main hall)

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