Survival Outcomes by Racial Differences Among Triple Negative Breast Cancer Patients: A Miami-Population Based Study

Background: African American (AA) women have a higher incidence of triple negative breast cancer (TNBC) and less favorable outcomes compared to Caucasian (CA) women. Racial differences on survival in Hispanic (H) women with... [ view full abstract ]

Background: African American (AA) women have a higher incidence of triple negative breast cancer (TNBC) and less favorable outcomes compared to Caucasian (CA) women. Racial differences on survival in Hispanic (H) women with TNBC has not been evaluated.

Methods:

451 TNBC patients were evaluated. The 5-year overall survival (OS) and disease free survival (DFS) were determined in patients undergoing surgery for TNBC stages I-III.

Results: Of the 451 TNBC patients, there were 130 AA, 199 H and 122 CA women. The median follow up was 47 months. AA women had more advanced T stage compared to both CA and H women (T3/T4: 29% AA, 18% H and 15% CA, p=0.03). The three groups had no statistical differences in N stage AJCC stage and treatment modalities. H women had a significant higher 5-year DFS (H – 68%; AA – 55%; CA- 61%; p=0.02) and a trend toward higher OS (H- 87%; AA-79%; CA – 85%; p=0.08), respectively. In Multivariate analysis adjusting for cancer stage, the H women had better 5-year DFS than the AA and CA groups (HR was 1.68 for AA and 2.02 for CA, p=0.018 and 0.002), respectively. No difference in OS or DFS between AA and CA were seen.

Conclusion: In our Hispanic majority metropolitan area, H women have better DFS compared to AA and CA women. Contrary to prior studies, our results showed no difference in OS or DFS between AA and CA women even when stratified for stage.