Tumor-activated prodrug nanoparticles sensing endogenous levels of matrix metallo-proteinase 2 in 3D tumor spheroids for the on-demand release of doxorubicin

Martina Profeta

Center for Advanced Biomaterials for health Care (CABHC), Istituto Italiano di Tecnologia, Centro di Ricerca Interdipartimentale sui Biomateriali (CRIB), Università di Napoli Federico II

Martina Profeta received her Master’s Degree in Biomedical Engineering cum laude from the University of Naples “Federico II” in July 2014, discussing an experimental thesis entitled “Tumor-Activated Prodrug Nanoparticles for Controlled Delivery of Doxorubicin”, under the supervision of Dr. Daniela Guarnieri and Prof. Paolo Netti. From November 2014 to now she is working as Ph.D. student at the “Istituto Italiano di Tecnologia (IIT)”, under the supervision of Prof. Paolo Netti. Her doctoral studies focus on the design of nanoparticles for extracellular drug release.At present, she is co-author of 2 publications in international peer-reviewed journals.

Abstract

Matrix Metalloproteinases (MMPs) are proteolytic enzymes that play a key role in tumor metastasis progression so a novel approach in nanoparticles (NPs) design may be the one that benefits from MMPs over-expression, in order... [ view full abstract ]

Authors

  1. Martina Profeta (Center for Advanced Biomaterials for health Care (CABHC), Istituto Italiano di Tecnologia, Centro di Ricerca Interdipartimentale sui Biomateriali (CRIB), Università di Napoli Federico II)
  2. Daniela Guarnieri (Center for Advanced Biomaterials for health Care (CABHC), Istituto Italiano di Tecnologia, Centro di Ricerca Interdipartimentale sui Biomateriali (CRIB), Università di Napoli Federico II)
  3. Valentina Belli (Center for Advanced Biomaterials for health Care (CABHC), Istituto Italiano di Tecnologia, Centro di Ricerca Interdipartimentale sui Biomateriali (CRIB), Università di Napoli Federico II)
  4. Marco Biondi (Dipartimento di Farmacia, Università di Napoli Federico II)
  5. Marco Cantisani (Center for Advanced Biomaterials for health Care (CABHC), Istituto Italiano di Tecnologia, Centro di Ricerca Interdipartimentale sui Biomateriali (CRIB), Università di Napoli Federico II)
  6. Luca Raiola (Center for Advanced Biomaterials for health Care (CABHC), Istituto Italiano di Tecnologia, Centro di Ricerca Interdipartimentale sui Biomateriali (CRIB), Università di Napoli Federico II)
  7. Paolo Antonio Netti (Center for Advanced Biomaterials for health Care (CABHC), Istituto Italiano di Tecnologia, Centro di Ricerca Interdipartimentale sui Biomateriali (CRIB), Università di Napoli Federico II)

Topic Areas

Targeted drug delivery and nanocarriers , Biological & medical nanodevices and biosensors

Session

OS1-A » Nanomedecine & Nanobiology (16:00 - Wednesday, 9th November, Auditorium)

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