Electrospun Nanocomposite Materials, A Novel Synergy of Polyurethane and Bovine Derived Hydroxyapatite
Abstract
Introduction: Polyurethane (PU) is one of the most reliable accompanying synthetic polymers that is used for construction of the scaffolds in tissue engineering applications in order to obtain desirable mechanical, physical... [ view full abstract ]
Introduction:
Polyurethane (PU) is one of the most reliable accompanying synthetic polymers that is used for construction of the scaffolds in tissue engineering applications in order to obtain desirable mechanical, physical and chemical properties like elasticity, durability and biocompatibility. Bovine derived hydroxyapatite (BHA) is a ceramic based natural polymers that is used as the most preferred implant material in orthopaedics and dentistry due to the chemically and biologically similarity to the mineral phase found in the human bone structure. As bone repair material, PU or PU scaffold loaded with nano-hydroxyapatite particles could enhance its bone-bonding bioactivity and mechanical properties [1]
Methods:
In this study, PU and bovine derived hydroxyapatite (BHA) solutions with different concentrations were prepared with dissolving polyurethane and BHA in dimethylformamide (DMF) and Tetrahydrofuran (THF) solutions. Blended PU-BHA solutions in different concentrations were used for electrospinning technique to create nanofiber scaffolds and new biocomposite material together.
Results and Discussion:
SEM, FTIR and physical characterization tests such as viscosity, electrical conductivity, density and tensile strength measurements were carried out after production process. In Figure 1, SEM images of the PU-BHA fibers were observed together as a scaffolds and bead like structures. Scaffolds were originated from the PU and reason of the bead like structures is the presence of the BHA.
Results are found to be promising for bone tissue engineering applications due to the characteristics of the composite nanofiber materials that possess both beneficial properties of two different material (PU and HAp) in same material.
Reference:
[1] Du JJ, Zou Q, Zuo Y, Li YB. Int J Surg 2014;12:404–7
Authors
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Yahya BOZKURT
(Marmara University, Department of Metallurgy and Materials Engineering, Faculty of Technology Goztepe Campus 34722, Kadikoy-Istanbul)
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Ahmet ŞAHİN
(Marmara University, Advanced Nanomaterials Research Laboratory, Department of Metallurgical and Materials Engineering, Goztepe Campus 34722 Istanbul)
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Akın SUNULU
(Marmara University, Bioengineering Department, Bachelor’s Degree, Faculty of Engineering, Istanbul 34722, Turkey)
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Mehmet Onur AYDOGDU
(Marmara University, Department of Metallurgical and Materials Engineering, Master of Science, Institute of Pure and Applied Sciences, Goztepe Campus 34722 Istanbul, Turkey)
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Faik Nüzhet OKTAR
(Marmara University, Bioengineering Department, Faculty of Engineering, Istanbul 34722)
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Nazmi EKREN
(Marmara University, Advanced Nanomaterials Research Laboratory, Department of Metallurgical and Materials Engineering, Goztepe Campus 34722 Istanbul)
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Oğuzhan GUNDUZ
(Marmara University, Department of Metallurgy and Materials Engineering, Faculty of Technology Goztepe Campus 34722, Kadikoy-Istanbul)
Topic Areas
Nanobiology and nanobiosystems , Nanofabrication, nanoprocesing & nanomanufacturing
Session
PS1 » Poster Session (13:30 - Wednesday, 9th November, Gallery)
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