Magnetically Targeted Delivery of Sorafenib to Liver Using Solid Lipid Nanoparticles for Treatment of Hepatocellular Carcinoma
Nicoletta Depalo
Istituto per i Processi Chimico-Fisici-CNR SS Bari
She is Research Scientist at the Institute for Chemical and Physical Processes (IPCF) of CNR Bari, with experience in the field of nanotechnology. Her research activities are mainly focused on the development of targeted drug delivery nanovectors or hybrid nanostructured bioconjugates, useful for imaging and/or treatment of specific diseases. She has expertise in synthesis, characterization and surface functionalization of colloidal nanoparticles (magnetic, plasmonic, silica based, carbon based, II-VI semiconductor and heterostructure materials), nanoparticle bioconjugation, protein and lipid purification, targeting strategies and methodologies suitable for the study of nano-bio interactions.
Abstract
Advanced hepatocellular carcinoma (HCC) is a clinical challenge with limited treatment options. The orally active multikinase inhibitor sorafenib is the only anticancer agent showing a survival benefit in these patients. As... [ view full abstract ]
Authors
- Nicoletta Depalo (Istituto per i Processi Chimico-Fisici-CNR SS Bari)
- Fabio Vischio (Istituto per i Processi Chimico-Fisici-CNR SS Bari)
- Ilaria Arduino (Università degli Studi di Bari Aldo Moro, Dipartimento di Farmacia, Scienze del Farmaco)
- Silvia Villa (Dipartimento di Chimica e Chimica Industriale, Università di Genova,)
- Fabio Canepa (Dipartimento di Chimica e Chimica Industriale, Università di Genova,)
- Elisabetta Fanizza (Università degli Studi di Bari Aldo Moro, Dipartimento di Chimica)
- Byung Chul Lee (Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam)
- Valentino Laquintana (Università degli Studi di Bari Aldo Moro, Dipartimento di Farmacia, Scienze del Farmaco)
- Angela Lopedota (Università degli Studi di Bari Aldo Moro, Dipartimento di Farmacia, Scienze del Farmaco)
- Annalisa Cutrignelli (Università degli Studi di Bari Aldo Moro, Dipartimento di Farmacia, Scienze del Farmaco)
- Maria Principia Scavo (Istituto Tumori IRCCS Giovanni Paolo II, Bari)
- Marinella Striccoli (Istituto per i Processi Chimico-Fisici-CNR SS Bari)
- Angela Agostiano (Università degli Studi di Bari Aldo Moro, Dipartimento di Chimica)
- M. Lucia Curri (Istituto per i Processi Chimico-Fisici-CNR SS Bari)
- Nunzio Denora (Università degli Studi di Bari Aldo Moro, Dipartimento di Farmacia, Scienze del Farmaco)
Topic Area
Targeted drug delivery and nanocarriers
Session
OS1b-A » Nanomedicine and nanobiotechnology (16:40 - Wednesday, 18th October, Auditorium)
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