Investigating intergenerational transmission of risk in a unique Norwegian extended twin-family sample

Genetically informative intergenerational studies can disclose modes of transmission ofrisk from parent to offspring. However, such studies have either relied on moderate samples where the offspring are distributed across a... [ view full abstract ]

Genetically informative intergenerational studies can disclose modes of transmission ofrisk from parent to offspring. However, such studies have either relied on moderate samples where the offspring are distributed across a wide range of developmental stages.

We will apply the extended children-of-twin design to the Norwegian Mother and Child Birth Cohort (n=90 000 families) where the offspring are assessed at several times at the same biological age. We will elaborate on extensions of the children-of-twin design to estimate both passive, active, and direct modes of transmission, and present examples using phenotypes such as ADHD, depression, substance use, and externalizing/internalizing behavior problems.