Equivalence of LD-Score Regression and Individual-Level-Data Methods

Abstract

LD-score (LDSC) regression disentangles the contribution of polygenic signal, in terms of SNP-based heritability, and population stratification, in terms of a so-called intercept, to GWAS test statistics. Whereas LDSC... [ view full abstract ]

Authors

  1. Ronald de Vlaming (VU Amsterdam)
  2. Magnus Johannesson (Stockholm School of Economics)
  3. Patrik KE Magnusson (Karolinska Institutet)
  4. M Arfan Ikram (Erasmus Medical Center)
  5. Peter M Visscher (University of Queensland)

Topic Area

Statistical Methods

Session

2A-OS » Methods (13:15 - Thursday, 29th June, Sal A)

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