Factors predicting favourable outcome for recovery of peri-operative neurological deficits in cranio-spinal intrinsic tumours: A single centre experience
Abstract
OBJECTIVES To review demographic, pathological and surgical factors that minimise long-term neurological deficits in cranio-spinal intrinsic tumours. DESIGN Retrospective analysis. SUBJECTS 33 patients with cranio-spinal... [ view full abstract ]
OBJECTIVES To review demographic, pathological and surgical factors that minimise long-term neurological deficits in cranio-spinal intrinsic tumours. DESIGN Retrospective analysis. SUBJECTS 33 patients with cranio-spinal intrinsic tumours located in eloquent areas treated at a single centre over a period of five years. METHODS From a cohort of 780 neuro-oncology patients, 33 (24 cranial and9 spinal) patients harbouring brain or spinal cord intrinsic tumours in eloquent areas were identified who had significant perioperative neurological deficits but near-complete recovery of the deficits within three months of surgical intervention. In addition to demographic data, technical factors related to surgery and tumour pathology were analysed to determine which factors may influence recovery of deficits. Surgical technical factors were studied for feasibility of gross macroscopic resection. RESULTS All patients who recovered from their deficits were less than 63 years of age, all except three patients had pathology ranging Gr I-III. In three patients, it wasGr IV. All except three had radical resection of tumour as proven by contrastimaging in the immediate post-operative period and at three months. Age, tumourgrade & extent of surgical resection appeared to be the factors influencingrecovery of neurological deficits. Younger age, lower grade of tumour and grosstotal excision of the tumour at surgery appeared to be favourable factors forrecovery of peri-operative deficits. CONCLUSIONS In a retrospectiveanalysis, younger age, lower grade of tumour and radical surgical excisionappear to be factors predicting favourable outcome for recovery ofperioperative neurological deficits in patients with cranio-spinal intrinsictumours.
Authors
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Kishor Choudhari
(Royal Hallamshire Hospitals, Sheffield Teaching Hospitals, Sheffield)
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Shashank Joshi
(Sevenhills Hospital, Andheri East, Mumbai 400059)
Topic Areas
Adult Gliomas , Meningiomas/ Schwannoma / Other
Session
OS-22C » Parallel Session C: Enhancing Survival/Nursing/AHP (09:00 - Thursday, 22nd June, Pentland West)
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