Body fat changes in adolescents diagnosed with gender dysphoria and treated with GnRH analogues and cross-sex hormones

Background

Body fat is preferably stored in the hip region in women and in the waist region in men. This results in a peripheral body fat distribution with a low waist-hip ratio (WHR) in women and a central fat distribution with a high... [ view full abstract ]

Aim(s)

The aim of this study is to determine the effects of endocrine treatment on total body fat, android body fat, gynoid body fat and WHR in adolescents with a GD diagnosis during GnRHa monotherapy and subsequently with the... [ view full abstract ]

Methods

This retrospective study included young adults diagnosed with GD (DSM-IV TR) in their teens and who were treated by a four-step protocol. This four-step protocol included psychological evaluation, treatment with GnRHa, the... [ view full abstract ]

Main Outcome Measures

Outcome measures include total body fat, android fat percentage, gynoid fat percentage and WHR in adolescents with a GD diagnosis during GnRHa monotherapy and subsequently with the addition of CSH. [ view full abstract ]

Results

24 transwomen and 31 transmen were included. GnRHa were started at a median age of 15.1 years (13.3-18.0), CSH were added at a median age of 17.6 years (15.4-19.1). In transwomen, during GnRHa monotherapy total body fat (TBF)... [ view full abstract ]

Conclusion

Conclusion and Discussion. During endocrine treatment TBF, gynoid fat and android fat increased in transwomen. This increase was most pronounced during GnRHa monotherapy coinciding with a higher increase in gynoid fat than in... [ view full abstract ]

Authors

  1. Maartje Klaver (VU University Medical Center, Department of Endocrinology and Center of Expertise on Gender Dysphoria, Amsterdam)
  2. Niek Van Regteren (VU University Medical Center, Department of Endocrinology and Center of Expertise on Gender Dysphoria, Amsterdam)
  3. Joost Rotteveel (VU Medical Center Amsterdam)
  4. Martin den Heijer (VU University Medical Center, Department of Endocrinology and Center of Expertise on Gender Dysphoria, Amsterdam)
  5. Daniel Klink (VU Medical Center Amsterdam)

Topic Area

Oral & Poster Topics: Children and adolescents

Session

OS-3B » Children & Adolescents III: Baseline and Follow-up Characteristics of Transgender Youth (11:15 - Saturday, 8th April, Atlantic 2)

Presentation Files

Presentatie_epath_Belgrade.ppt