A novel biological device to secure and protect neophallus penile prosthesis cylinders and the neourethra for phalloplasty: acellularized while penile Tunica & Glans tissues made from human penis following vaginoplasty

Background

Common risks/challenges related to penile prosthesis placement after phalloplasty in transgender men are: 1. Migration of the penile prosthetic cylinder(s) within the neophallus base and shaft; and 2. Extrusion of a component... [ view full abstract ]

Aim(s)

1. We propose that human penis specimens (freshly harvested during MtoF GCS vaginoplasty surgery, or cadaveric) can serve as a source from which to harvest intact (i.e. still tubularized) penile Tunica tissue for processing to... [ view full abstract ]

Main Outcome Measures

We used 5 human penises discarded following MtoF vaginoplasty surgery. While these did not include a portion of the glans, the entire neurovascular bundle, and the proximal urethra, the specimen’s Tunica was completely... [ view full abstract ]

Methods

Gross and histologic assessment of human tunica and glans tissues after chemical treatment to render them acellular Use of an inflatable penile prosthesis and a radial artery forearm flap neophallus with neourethra to... [ view full abstract ]

Results

Tunical tissues remained completely intact after chemical processing. Length was preserved. Immunohistochemistry revealed no residual cellular material in 4/5 specimens after chemical processing for 30-days, and questionable... [ view full abstract ]

Conclusion

Chemical processing for at least 30 days rendered all specimens acellular/devoid of protein. This should render the matrices non-immunogenic. The proposed device (Patents Pending) offers numerous potential safety and... [ view full abstract ]

Authors

Maurice Garcia (University of California San Francisco), Lia Banie (University of California San Francisco), Guiting Lin (University of California San Francisco)

Topic Area

Oral & Poster Topics: Surgery

Session

OS-3E » Surgery III: Phalloplasty: Techniques, Outcomes, and Complications (11:15 - Saturday, 8th April, Aegean)

Presentation Files

The presenter has not uploaded any presentation files.