Can oestrogen suppress androgen production in male to female transsexuals

Freya Lawrence

University of Glasgow

Fourth year medical student at the University of Glasgow. I spent last summer carrying out an elective at the Sandyford in Glasgow, where I spent most of my time with the Gender Identity team. I have an increased interest in the field of Transgender Health which was sparked by this, and I look forwards to learning more about this fast advancing field at my first Trans Health conference. 

David Gerber

Sandyford Initiative

Consultant psychiatrist. Clinical Lead for Transgender and Psychosexual Services, Sandyford. Lead Clinical National Gender Identity Clinical Network for Scotland.


Antiandrogen use in male to female transgender patients is recommended by a variety of guidelines. Some clinics had, prior to these guidelines, not routinely used antiandrogen therapy - and there are some reports of up to 60%... [ view full abstract ]


To establish the proportion of male to female transgender patients presenting to the Sandyford Gender Service who suppress androgen production with oestrogen alone. [ view full abstract ]


A retrospective sample of male to female transgender people referred to the Gender Service in 2011/2012 was used. Their clinical notes were analysed using an Excel database. [ view full abstract ]

Main Outcome Measures

Proportion patients referred in 2011/2012 to the Sandyford Gender Service who suppress testosterone on oestrogen alone. [ view full abstract ]


19.3% of the sample did suppress testosterone on oestrogen alone. This number may have been higher in reality as a proportion of patients were placed on antiandrogens without being given the opportunity to self-suppress on... [ view full abstract ]


There is a group of patients who will suppress androgen production without the need for antiandrogen use. This may reduce exposure to additional side effects and associated risk. We recommend that male to female transgender... [ view full abstract ]


  1. Freya Lawrence (University of Glasgow)
  2. David Gerber (Sandyford Initiative)

Topic Area

Oral & Poster Topics: Endocrinology


OS-1C » Endocrinology I (14:00 - Thursday, 6th April, Atlantic 3)

Presentation Files

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