Neural correlates of social rejection sensitivity in trans persons on cross-sex hormone therapy


Trans persons continue to be stigmatized and marginalized in society. However, little is known how the experience of social rejection manifests at the neurobiological level. [ view full abstract ]


To assess the neurobiological correlates of social rejection experience in trans persons on cross-sex hormone therapy. [ view full abstract ]


In the present study, 20 trans men, 19 trans women, 20 cisgender men and 20 cisgender women completed a computerized social rejection task, the cyberball task, whilst undergoing fMRI scanning. This task includes a game of... [ view full abstract ]

Main Outcome Measures

Neural activations during the exclusion relative to the inclusion condition and the social re-inclusion after exclusion condition. Moreover, functional connectiovity analyses (PPI) were also conducted, which assess the... [ view full abstract ]


During the experience of social exclusion, cisgender women showed neural activations in the inferior frontal gyrus (IFG) and anterior cingulate cortex (ACC), regions involved in behavioral control and affective regulation,... [ view full abstract ]


The present findings highlight the neurobiological correlates of the processing of social rejection experience, particularly in trans men. [ view full abstract ]


  1. Sven Mueller (Ghent University)
  2. Katrien Wierckx (Ghent University)
  3. Guy T'Sjoen (Ghent University)

Topic Area

Oral & Poster Topics: Endocrinology


OS-3C » Endocrinology III: Neurobiology (11:15 - Saturday, 8th April, Atlantic 3)

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