Testosterone therapy does not always induce amenorrhea in female to male transgender subjects

Giovanna Motta

University of Torino/Department of Medical Sciences/Endocrinology, Diabetology and Metabolism

Since 2007 she has been attending the Division of Endocrinology and Metabolism (Chairman Prof. E.Ghigo) of the University of Turin, first as a medical student (2007-2010), then as trainee at the Post-graduate School in Endocrinology and Metabolism (2010-2015). In the last years her clinical practice has been mainly focused on the management of pathological conditions in Andrology and Reproductive Medicine. Since 2013 she has been working as Endocrinologist in the clinical management of gender dysphoria in the Turin Gender Team.Now she is a PhD student in Medical Physiopathology at the University of Turin with a PhD program about gender dysphoria.  

Background

Transgender men are persons assigned female at birth but who identify themselves as men. Cross sex testosterone therapy is the milestone of medical treatment for transgender men; its aim is to achieve serum testosterone... [ view full abstract ]

Aim(s)

The aim of our retrospective study was to find differences between Female to Male (FtM) subjects achieving amenorrhea (group 0) and FtM subjects with persistent menses (group 1) after 1 year of continuous testosterone treatment. [ view full abstract ]

Methods

In our gender dysphoria clinic in Turin 50 FtM subjects were retrospectively analysed before (T0) and after 1 year (T1) of continuous testosterone treatment. At T0 age, BMI, serum testosterone and estradiol levels have been... [ view full abstract ]

Main Outcome Measures

Achievement of amenorrhea and second line treatment in case of persisting bleedings at T1 were the main outcomes of our study. [ view full abstract ]

Results

After 12 months of continuous testosterone treatment, all patients reached male serum testosterone levels (5,13 [3,78-7,62] ng/ml) and attained a satisfactory body virilization. 64 % of our sample obtained amenorrhea (group... [ view full abstract ]

Conclusion

In conclusion, one year testosterone therapy in FtM transgender subjects lead to a good body virilization and reduces gender dysphoria distress, although more than one third of subjects did not obtain amenorrhea. Since the... [ view full abstract ]

Authors

  1. Giovanna Motta (University of Torino/Department of Medical Sciences/Endocrinology, Diabetology and Metabolism)
  2. Chiara Crespi (Centro Interdipartimentale Disturbi Identità di Genere Molinette (C.I.D.I.Ge.M)/Torino)
  3. Valentina Mineccia (Centro Interdipartimentale Disturbi Identità di Genere Molinette (C.I.D.I.Ge.M)/Torino)
  4. Anna Gualerzi (Centro Interdipartimentale Disturbi Identità di Genere Molinette (C.I.D.I.Ge.M)/Torino)
  5. Fabio Lanfranco (University of Torino/Department of Medical Sciences/Endocrinology, Diabetology and Metabolism)
  6. Chiara Manieri (Centro Interdipartimentale Disturbi Identità di Genere Molinette (C.I.D.I.Ge.M)/Torino)

Topic Area

Oral & Poster Topics: Endocrinology

Session

OS-1C » Endocrinology I (14:00 - Thursday, 6th April, Atlantic 3)

Presentation Files

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