Using liquid chromatography tandem mass spectrometry to measure steroid hormone profiles in gender dysphoria (GD) patients in a multi-Center setting

Florian Josef Schneider

Institute of Reproductive and Regenerative Medicine, Center of Reproductive Medicine and Andrology

Dr. Florian Josef Schneider is currently in training for pediatrics and neonatology in Muenster, Germany. He is involved in research at the Center for Reproductive Medicine and Andrology of the University Clinic in Muenster among Prof. Zitzmann, Prof. Schlatt and Prof. Kliesch since 2012. His main focus is testicular morphology of patients diagnosed with gender dysphoria and stem cell cultivation. 

Background

Little information is available on cross-sex hormone therapy (CHT) in gender dysphoria (GD) patients on the day of sex-reassignment surgery (SRS). To achieve initial physical adaptation in male-to-female GD patients,... [ view full abstract ]

Aim(s)

To assess the effects of three different treatment regimens of CHT until SRS on the adrenal and gonadal steroid profile. [ view full abstract ]

Methods

Ethical approval was received for this research prior to study initiation and written informed consent was recieved before study participation. The first 15 patients obtained from three independent clinics were selected.... [ view full abstract ]

Main Outcome Measures

Questionnaires for age, weight, height and intake of medication were collected. Thirteen steroid hormones were evaluated by liquid-chromatography - tandem mass spectrometry, 7 sex hormones by immunofluorometric assays and... [ view full abstract ]

Results

Mean 11-deoxycorticosterone levels of clinic B (* p < 0.05) were decreased compared to clinic A. Mean 21-deoxycortisol was significantly higher in clinic C compared to clinic B (**** p < 0.00001). Cortisone levels were... [ view full abstract ]

Conclusion

In this first descriptive study examining the adrenal and gonadal hormone profile in GD patients on the day of SRS, we could demonstrate, that CHT had the most marked effect on the sex-steroid axis. Reduced stress hormone... [ view full abstract ]

Authors

  1. Florian Josef Schneider (Institute of Reproductive and Regenerative Medicine, Center of Reproductive Medicine and Andrology)
  2. Joachim Wistuba (Institute of Reproductive and Regenerative Medicine, Center of Reproductive Medicine and Andrology)
  3. Michael Zitzmann (Department of Clinical and Surgical Andrology, Center of Reproductive Medicine and Andrology)
  4. Paul-Martin Holterhus (Hormone Centre for Children and Adolescents, Department of Pediatrics, University Hospital Schleswig-Holstein)
  5. Alexandra Kulle (Hormone Centre for Children and Adolescents, Department of Pediatrics, University Hospital Schleswig-Holstein)
  6. Stefan Schlatt (Institute of Reproductive and Regenerative Medicine, Center of Reproductive Medicine and Andrology)
  7. Nina Neuhaus (Institute of Reproductive and Regenerative Medicine, Center of Reproductive Medicine and Andrology)

Topic Area

Oral & Poster Topics: Endocrinology

Session

OS-1C » Endocrinology I (14:00 - Thursday, 6th April, Atlantic 3)

Presentation Files

The presenter has requested not to share their files.