Anti-Mullerian Hormone serum levels remain stable under cross-sex hormone therapy of transgender men

Yona Greenman

Tel Aviv-Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University

Deputy Director of the Institute of Endocrinology and Metabolism, Tel Aviv-Sourasky Medical Center, Director of the Neuroendocrine UnitAssociate Professor -Sackler Faculty of Medicine, Tel Aviv UniversityTreating trans-people for more than 15 years- I am glad to have introduced the subject to the internal medicine curriculum of the Sackler Medical School, and in the  requirements for specialist certification  in Endocrinology in Israel.

Background

Although successful pregnancies carried by transgender men have been reported, long-term effects of testosterone therapy on fertility remain unknown. [ view full abstract ]

Aim(s)

To study markers of ovarian reserve during testosterone therapy. [ view full abstract ]

Main Outcome Measures

Prospective open-label study of transgender men prior and during treatment with IM Testoviron Depot 250 mg q3 weeks. Sampling was conducted in the follicular phase at baseline and 10 days after injection three and 12 months... [ view full abstract ]

Methods

Anti-mullerian hormone (AMH) serum levels; endometrial thickness and antral follicular count determined by pelvic US. [ view full abstract ]

Results

Thirty five subjects (mean age 24±5.9 y) were included. Preliminary results of twenty two patients with at least one follow up visit are reported. AMH levels were within the normal range (5.8±2.9 ng/ml) and did not change... [ view full abstract ]

Conclusion

AMH levels remain stable during short term testosterone treatment. Further, there is no suppression of the hypothalamo-pituitary-gonadal axis and ovarian folliculogenesis is maintained. Longer follow up is needed for... [ view full abstract ]

Authors

Iris Yaish (Tel Aviv-Sourasky Medical Center), Gustavo Malinger (Tel Aviv-Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University), Yael Sofer (Tel Aviv-Sourasky Medical Center), Mariana Yaron (Tel Aviv-Sourasky Medical Center), Dana Zaid (Tel Aviv-Sourasky Medical Center), Foad Azem (Tel Aviv-Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University), Naftali Stern (Tel Aviv-Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University), Yona Greenman (Tel Aviv-Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University)

Topic Area

Oral & Poster Topics: Endocrinology

Session

OS-2C » Endocrinology II (11:00 - Friday, 7th April, Atlantic 3)

Presentation Files

AMH-_EPATH_2017_final.pptx