Preservation of bone mineral density after 10 years of cross-sex hormonal treatment in trans persons


Cross-sex hormonal treatment (CHT) in trans persons affects bone mineral density (BMD) on short term. However, long-term follow-up studies investigating the effects of CHT on BMD are lacking. [ view full abstract ]


The aim of this study is to investigate the change in BMD after 10 years of CHT in both trans women and trans men. [ view full abstract ]


A retrospective cohort study was performed in adult trans women and trans men treated with cross-sex hormones at the VU University Medical Center Amsterdam (the Netherlands) since 1998. Persons were included for analyses if... [ view full abstract ]

Main Outcome Measures

Mean change in lumbar spine (LS) BMD expressed as T-score and age-matched Z-scores were analyzed and were stratified for age groups (18 to 30, 31 to 49, and ≥50 years), prior cross-sex hormone use, and the occurrence of... [ view full abstract ]


71 trans women (mean age: 37 years, standard deviation (SD)±10 years) and 38 trans men (mean age: 33 years, SD±8 years) were included. In trans women, baseline mean T-score was -0.67 (SD±1.28) and mean Z-score -0.55... [ view full abstract ]


In both trans women and trans men, LS BMD was preserved after 8 to 12 years of CHT. However, as most persons were passed the age of peak bone mass achievement, the natural course of BMD is to decrease. Therefore, unchanged... [ view full abstract ]


  1. Chantal Wiepjes (VU Medical Center Amsterdam)
  2. Mariska Vlot (VU Medical Center Amsterdam)
  3. Christel de Blok (VU Medical Center Amsterdam)
  4. Nienke Nota (VU Medical Center Amsterdam)
  5. Maartje Klaver (VU Medical Center Amsterdam)
  6. Martin den Heijer (VU Medical Center Amsterdam)

Topic Area

Oral & Poster Topics: Endocrinology


OS-1C » Endocrinology I (14:00 - Thursday, 6th April, Atlantic 3)

Presentation Files

The presenter has not uploaded any presentation files.