The combination of nucleic acids chemistry (e.g., nucleoside, nucleotides, oligonucleotides) with supramolecular principles provides an efficient and powerful approach to prepare well-defined systems with tunable physico-chemical properties and functions. We develop new nano-systems based on nucleic acids chemistry for i) drug delivery applications (therapeutic, theranostic), and ii) tissue engineering. This communication will present novel “smart” nucleic acid derivatives (nucleolipids, lipid-oligonucleotide conjugates) developed in our lab [1].
References
[1]
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- Oumzil, K. Benizri, S. Tonelli, G. Staedel, C. Appavoo, A. Chaffanet, M. Navailles L. and Barthélémy P. (2015) ChemMedChem DOI: 10.1002/cmdc.201500381
- Luvino, D. ; Khiati, S. ; Oumzil, K. ; Rocchi, P. ; Camplo, M. ; and Barthélémy P. (2013) J. Control. Release, 172, 954–961
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- Moreau, L., Camplo, M., Wathier, M., Taib, N., Laguerre, M., Bestel, I., Grinstaff, M.W., Barthélémy, P. (2008) J. Am. Chem. Soc. 130, 14454-14455.
Nanomedecine for cancer diagnosis & therapy , Tissue engineering and regenerative nanomedicine