Magnetoplasmonic nanoparticles for use in Nanotherapy

Introduction  Photonic therapy, can treat tumors either through photothermal effect using a photothermal agent (PTA) for selective localised heating, or through photo-dynamic therapy using photosensitizers (PS) for a series... [ view full abstract ]

Introduction

 Photonic therapy, can treat tumors either through photothermal effect using a photothermal agent (PTA) for selective localised heating, or through photo-dynamic therapy using photosensitizers (PS) for a series of photochemical reactions. Many plasmonic nanoparticles can serve both as PTA and PS for stimulation in the visible and infra-red region of the optical spectra (optical stimulation). Magnetic hyperthermia (MH) based therapy [1-3] can be combined with optical photothermal stimulation. This dual therapy has been shown to be highly effective in-vitro and in-vivo in comparison to either therapy used individually[4].

Method

NANOCARGO, introduces a new paradigm that nanotherapy can be made far more effective if a multimodal action can be integrated by adding a plasmonic shell to a magnetic nanoparticle core. The development of drug resistance in tumor cells plays a major role in the failure of current cancer therapies. To overcome the drug resistance NANOCARGO with photo-magnetic properties can be developed along with simultaneous diagnosis and therapy (theranostics) approach. The plasmonic shell can be functionalized with chemotherapeutic drugs and aptamars. These nanocargos can be simultaneously simulated through magnetic hyperthermia and photonic therapy. 

Results and Discussion

 Anticancer therapy is thus made more effective through the multimodal stimulation of these nanocargos, minimally invasive optical stimulation and extracorporeal magnetic resonance imaging based excitation. Showing promise for a minimally invasive procedure offering personalisation of cancer therapy.

[1] Shete,P.B.,et al. Applied Surface Science 288(2014):149-157.

[2] Thorat,Nanasaheb.,et al. ACS applied materials & interfaces 8.23(2016):14656-14664.

[3] Thorat,Nanasaheb.,et al. Physical Chemistry Chemical Physics 18.31(2016):21331-21339.

[4] Espinosa, Ana,et al. ACS nano 10.2(2016):2436-2446.

[5] Levin,Carly,.et al.  ACS nano 3.6(2009):1379-1388. 

This work is supported by Science Foundation Ireland(SFI) CÚRAM funding and Government Of Ireland(GOI) Postdoctoral Fellowship by Irish Research Council(IRC).