New Polymers and Strategies for Drug Delivery Applications

This lecture will present our recent achievements in the field of macromolecular engineering for biomedical applications, and especially the use of controlled radical polymerization as a tool for the design of polymer prodrug... [ view full abstract ]

This lecture will present our recent achievements in the field of macromolecular engineering for biomedical applications, and especially the use of controlled radical polymerization as a tool for the design of polymer prodrug nanoparticles.¹ We developed of new class of polymer prodrug nanoparticles by using the "drug-initiated" method (see Figure),² which consisted in the controlled growth of hydrophobic polymers from anticancer drug-bearing alkoxyamines or chain transfer agents to prepare, by NMP or RAFT, well-defined and high drug content polymer prodrug nanoparticles with in vitro and in vivo anticancer activity.^3,4 Degradability will also be conferred to those materials by using radical ring-opening polymerization (rROP) from cyclic ketene acetal (CKA) monomers.^5,6,7

References

1. Delplace, V.; Couvreur, P.; Nicolas, J. Polym. Chem. 2014, 5, 1529

2. Nicolas, J. Chem. Mater. 2016, 28, 1591

3. Harrisson, S.; Nicolas, J.; Maksimenko, A.; Bui, D. T.; Mougin, J.; Couvreur, P. Angew. Chem., Int. Ed. 2013, 52, 1678

4. Bao, Y.; Boissenot, T.; Guégain, E.; Desmaële, D.; Mura, S.; Couvreur, P.; Nicolas, J. Chem. Mater. 2016, 28, 6266

5. Delplace, V.; Nicolas, J. Nature Chem. 2015, 7, 771

6. Tardy, A.; Nicolas, J.; Gigmes, D.; Lefay, C.; Guillaneuf, Y. Chem. Rev. 2017, 117, 1319

7. Delplace, V.; Guégain, E.; Harrisson, S.; Gigmes, D.; Guillaneuf, Y.; Nicolas, J. Chem. Commun. 2015, 51, 12847