Advances in nanotechnology, biotechnology, and materials sciences are leading to novel approaches in the field of health science and technology. Effective integration of biological units in these new technologies is critical for interfacing biological functions. As an alternative to synthetic polymers, biomolecules such as nucleic acids, amino acids, sugars represent valuable bioorganic material for the construction of biomedical devices due to their general biocompatibility and their supramolecular properties. While the utility of synthetic biomolecules for biomedicine has been demonstrated through a number of reports, an undeveloped potential for more effectively using the molecular and supramolecular capabilities of bioconjugates in nanomedicine remains to be explored.
In this presentation we will see how the synthetic combination of biomolecules, (i.e. nucleic acids sugars, lipids) provides an efficient approach to prepare well-defined nano systems with tunable physico-chemical properties and functions. The new bioinspired systems are currently under investigation in our lab for i) drug delivery applications (therapeutic, theranostic), and ii) biomaterials.[1]
References
[1]
- Ramin M.A., Latxague L., Sindhu K.R., Chassande O., Barthélémy P., (2017) “Low molecular weight hydrogels derived from urea based-bolaamphiphiles as new injectable biomaterials” Biomaterials doi: 10.1016/j.biomaterials.2017.08.034.
- M. A. Ramin, K. R. Sindhu, A. Appavoo, K. Oumzil, M. W. Grinstaff, O. Chassande, P. Barthélémy, (2017) “Cation Tuning of Supramolecular Gel Properties: A New Paradigm for Sustained Drug Delivery” Adv. Mater. DOI: 10.1002/adma.201605227.
- S.Karakia, S. Benizrie, R. Mejíasa, V. Baylota, N. Branger, T. Nguyen, B. Vialet, K. Oumzil, P. Barthélémy, P. Rocchi (2017) “Lipid-oligonucleotide conjugates improve cellular uptake and efficiency of TCTP-antisense in castration-resistant prostate cancer”, Journal of Controlled Release 258, 1–9
- K. Oumzil, M. A. Ramin, C. Lorenzato, A. Hemadou, J. Laroche, M. J. Jacobin-Valat, S. Mornet, C.-E. Roy, T. Kauss, K. Gaudin, G. Clofent-Sanchez, and P. Barthélémy (2016) “Solid Lipid Nanoparticles for Image-Guided Therapy of Atherosclerosis.” Bioconjugate Chemistry 27 (3), pp. 569-575
- Latxague, L., Ramin, M.A., Appavoo, A., Berto, P., Maisani, M., Ehret, C., Chassande, O., and Barthélémy, P. (2015) Angewandte Chemie, DOI: 10.1002/ange.201409134.
Targeted drug delivery and nanocarriers , Nanomedicine for cancer diagnosis & therapy , Tissue engineering and regenerative nanomedicine
