DNA chips and related sensors based on dendrimers. Towards rapid and accurate diagnosis of pathogens

Dendrimers [1] are perfectly defined hyperbranched nanomolecules, which possess many biological properties. [2] They can be used as 3-dimensional linkers between a solid surface and a bioprobe, for improving the sensitivity of... [ view full abstract ]

Dendrimers [1] are perfectly defined hyperbranched nanomolecules, which possess many biological properties. [2] They can be used as 3-dimensional linkers between a solid surface and a bioprobe, for improving the sensitivity of sensors. [3] Three main advantages are expected when using dendrimers instead of classical (linear) linkers for the elaboration of microarrays: i) an increase of the density of probes per unit surface, ii) a greater accessibility of the target to the probe, and iii) a larger spacer from the glass surface avoiding unspecific interactions. 

From fundamental researches [4] to commercial kits for determining the best treatment to prescribe in the context of personalized medicine, [5] the advantages of using dendrimers will be emphasized.

[1] Dendrimers. Towards Catalytic, Material and Biomedical Uses. Caminade A.M., Turrin C.O., Laurent R., Ouali A., Delavaux-Nicot B, Eds. 21 chapitres, 528 pages, John Wiley & Sons, Chichester (UK), September 2011. ISBN: 978-0-470-74881-7

[2] Caminade A.M., Fruchon S., Turrin C.O., Poupot M., Ouali A., Maraval A., Garzoni M., Maly M., Furer V., Kovalenko V., Majoral J.P., Pavan G.M., Poupot R. Nature Comm. 2015, 6, 7722 

[3] Feng C.L., Zhong X.H., Steinhart M., Caminade A.M., Majoral J.P., Knoll W. Small 2008, 4, 566-571.

[4] a) Le Berre V., Trevisiol E., Dagkessamanskaia A., Sokol S., Caminade A.M., Majoral J.P., Meunier B., François J. Nucleic Acids Res. 2003, 31, e88.1-e88.8; b) Trévisiol E., Leberre-Anton V., Leclaire J., Pratviel G., Caminade A.M., Majoral J.P., François J.M., Meunier B. New J. Chem. 2003, 27, 1713-1719.

 [5] Dendris: http://www.dendris.fr/