Modification of Fe3O4-Au dumbbell nanoparticles with fluorescent dyes and drugs for new opportunities in biomedical application

Alexandra Prelovskaya

National University of Science and Technology «MISiS»

Aleksandra Prelovskaia is a researcher in «Biomedical Nanomaterials» laboratory, which is a collaboration of NUST «MISiS». On the Conference she presents the results of her scientific activity during work in laboratory. The area of scientific interest: magnetic nanoparticles, magnetite-gold hybrid structures, targeted drug delivery systems, magnetic hyperthermia, thermotherapia, magnetic resonance imaging, fluoresent dyes.

Mariia Efremova

National University of Science and Technology «MISiS»

Mariia V. Efremova presents the results of work, obtained in «Biomedical Nanomaterials» laboratory, which is a collaboration of NUST «MISiS» and Lomonosov Moscow State University. She is a 3rd-year PhD student. Mariia has had several internships abroad (USA, Japan, Germany) and currently participates in a joint research with the group of M. Farle (University of Duisburg-Essen, Duisburg, Germany). Mariia has several publications in international journals (Angewandte Chemie International Edition, Colloids and Surfaces B: Biointerfaces, Materials Letters). The area of scientific interest: magnetic nanoparticles, magnetite-gold hybrid structures, targeted drug delivery systems, magnetic resonance imaging, chemical enzymology, distant regulation of biomolecules activity.

Abstract

Recent developments in nanotechnology and molecular biology have helped to translate multifunctional magnetic nanoparticles into medical application. From a number of diseases, cancer is one of the major cause of death due to difficulty in accurate diagnosis and treatment of this. Early detection and treatment of cancer are critical factors for a favorable prognosis.
Thus, new possibilities in nanotechnology area are related with so called theranostics, which are defined as a material for the combination of therapy and imaging within a single platform.

Hybrid materials based on nanoparticles with different surface nature as well as different chemical properties represent particularly especial interest. Such materials can be controlled modified in various ways simultaneously, in particular with drugs and targeted molecules [1]. Surface modification of nanoparticles with fluorescence dyes opens horizons for visualization capabilities, also allows us to trace the behavior of particles in a biological environment, which is essential for their future biomedical applications [2].
In this work we developed synthetic procedure for magnetite-gold dumbbell nanoparticles modified with different copolymers containing: fluorescein and sulfo-Cy5 and investigated of the similar system with a drug (doxorubicin) instead of the dye. Next, in vitro biodistribution of nanoparticles was studied on LNCaP cell line (PSMA-positive prostate cancer cell line). More detailed information for the synthesis, characterization and biological testing will be discussed in report.

The authors gratefully acknowledge the support of the Ministry of Education and Science of the Russian Federation (grant № 14.578.21.0201 (RFMEFI57816X0201)).

[1] Fang-hsin Lin and Ruey-an Doong. Bifunctional Au−Fe₃O₄ Heterostructures for Magnetically Recyclable Catalysis of Nitrophenol Reduction. J. Phys. Chem. C., 115 (14) (2011)

[2] Vladislav Verkhusha et al .Modern Fluorescent Proteins and their Biological Applications. BioTechniques, Vol. 51, No. 5 (2011)

Authors

Alexandra Prelovskaya (National University of Science and Technology «MISiS»)
Mariia Efremova (National University of Science and Technology «MISiS»)
Anastasia Garanina (National University of Science and Technology «MISiS»)
Nurgustaana Neustroeva (National University of Science and Technology «MISiS»)
Tatiana Abakumova (Pirogov Russian National Research Medical University)
Pavel Melnikov (Department of Fundamental and Applied Neurobiology, Serbsky Medical Research Center of Psychiatry and Narcology, Moscow, Russia)
Maxim Abakumov (Pirogov Russian National Research Medical University)
Alexander Savchenko (National University of Science and Technology «MISiS»)
Alexander Majouga (Lomonosov Moscow State University)

Topic Areas

Nanomedicine for cancer diagnosis & therapy , Nano-Imaging for diagnosis, therapy and delivery

Session

PS2 » Poster Session (13:30 - Tuesday, 26th September, Gallery)

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