Valuable phosphorous compounds for catalysis — Access via arynes and element/lithium exchange

The reaction of aryllithiums or lithium phosphides with in situ generated arynes was used to access non-symmetric biphenylphosphines or dibenzophospholes, with diverse substitution pattern. Axial or central chirality could be... [ view full abstract ]

The reaction of aryllithiums or lithium phosphides with in situ generated arynes was used to access non-symmetric biphenylphosphines or dibenzophospholes, with diverse substitution pattern. Axial or central chirality could be controlled by means of either post-coupling deracemization or desymmetrization, or directly by atropo-diastereoselective coupling. In these processes as well as in the functionalization of resulting products, halogen/lithium or sulfoxide/lithium exchanges were used as versatile tools. The phosphines obtained were evaluated in catalysis.^[1]

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