Implementing routine pre-emptive DPD testing with adaptive dosing to secure 5-FU administration: Performance in digestive and head-and-neck cancer patients

Manon Launay

Laboratory of pharmacology - European Hospital Georges Pompidou

Pharmacist by training, Manon Launay completed her formation with a diploma of higher education specialized in hospital pharmacy and a PhD in clinical pharmacology applied to oncology in Marseille. Her PhD research objective was to secure chemotherapy using 5-Fluorouracil.


Introduction: Fluoropyrimidines are a mainstay in the treatment of numerous solid tumors. Most of the administered 5-FU dose will undergo extensive liver catabolism driven by dihydropyrimidine dehydrogenase (DPD). Drug dosing... [ view full abstract ]


  1. Manon Launay (Laboratory of pharmacology - European Hospital Georges Pompidou)
  2. Sebastien Salas (Medical oncology unit - La Timone)
  3. Laetitia Dahan (Digestive oncology Unit - La Timone)
  4. Jean-françois Seitz (Digestive oncology Unit - La Timone)
  5. Florence Dufaud (Medical oncology unit - La Timone)
  6. Bruno Lacarelle (laboratory of pharmacokinetics - La Timone)
  7. Joseph Ciccolini (laboratory of pharmacokinetics - La Timone)

Topic Areas

Personalized therapies (cancer, immunology, infectious diseases, clinical case studies, et , Emerging opportunities in personalized medicine, cutting-edge new strategies and solutions


OS3b-A » Multi-Topics (16:00 - Wednesday, 27th June, Amphitheater)

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