Whole-genome sequences of Hantaan virus and geological information system reveals the infection site of military HFRS patients in Republic of Korea

Hantaan viruses (HTNV), a sub-family of Hantavirus, has been known as etiologic agents of Hemorrhagic Fever Renal Syndrome (HFRS) in Old World and posed serious biological threats to military and civilian personnel. After the... [ view full abstract ]

Hantaan viruses (HTNV), a sub-family of Hantavirus, has been known as etiologic agents of Hemorrhagic Fever Renal Syndrome (HFRS) in Old World and posed serious biological threats to military and civilian personnel. After the first finding of Hantaan virus near Hantaan River in 1976 from its host Apodemus agarius, many subtype of Hantavirus, such as Seoul virus, Muju virus and Imjin virus, have been isolated and sequenced in Korea. Through carrying out comparative genomics project, which is international collaboration project between ROK and US, we have constructed a local database which contains more than 10,000 entries of Hantavirus hosts captured during 2000~2017 in South Korea. Users can easily access hosts’ detail information as well as HTNV genome sequences through the web interface. This locally constructed HTNV hosts databases information is connected with geological information system. The geological location and distribution of captured hosts and human patients are also easily accessed by web interface. By phylogeographic analysis of HTNV whole genome sequences, the infection site of HTNV patients is intuitively provided as starting point for epidemiologic investigation. In this poster, we will introduce several cases which have been used as elucidated infection site of HTNV in military patients.