(58) Synthesis and characterization of platinum indazole complexes with potential anti-cancer activity

     Platinum complexes such as cisplatin and its derivatives have been used extensively in cancer treatment for several decades despite a wide array of significant side effects including cytotoxicity and developed... [ view full abstract ]

     Platinum complexes such as cisplatin and its derivatives have been used extensively in cancer treatment for several decades despite a wide array of significant side effects including cytotoxicity and developed resistance. More recently, complexes based on other metals, noticeably ruthenium, have begun to be recognized as possible alternatives.  Of particular note is the anionic indazole complex [RuCl₄(Ind)²]^-, which has displayed promising behavior as a chemotherapeutic agent with low toxicity, selective activity and decreased resistance. While this novel ruthenium complex has already entered clinical trials, its mode of action remains relatively poorly understood. As part of a larger effort to build on these two threads of inquiry, we have recently prepared and characterized indazole complexes of platinum(II) and platinum(IV) as analogs to both cisplatin and [RuCl₄(Ind)²]^-.  In addition to spectroscopic characterization, we have confirmed the structure of several complexes crystallographically.